Mimulus Project

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Due to tremendous ecological and phenotypic diversity, the genus Mimulus (Scrophulariaceae, order Lamiales) has been widely used as a superb model flowering plant system for ecological and evolutionary genetics. All species are hermaphroditic and self-fertile, facilitating the construction of permanent populations such as inbred lines and recombinant inbred lines (RIL). M. guttatus species complex (2n = 28) and M. lewisii (2n = 16) are two established study systems. Both display tremendous variation in traits directly related to reproductive isolation in the wild, including habitat speciation, floral divergence, and the fertility of hybrids.

They generate the shared material and infrastructure necessary for community-wide comparative studies within Mimulus and among flowering plants. The exploitation of comparative genomic tools facilitates dissection of the QTLs recently identified as the key regions in speciation in the two different sections of the genus, down to the individual genes. This work will help to identify and characterize important genes underlying adaptation and speciation in plants. A detailed understanding of the molecular genetic basis of speciation will allow the testing of many long-standing hypotheses about the development of species barriers.

CUGI's role
CUGI has partnered with other research institutions to help provide a robust set of genetic resources for the Mimulus community. CUGI's role in the collaborative effort consists of BAC library construction for both Mimulus guttatus and Mimulus lewisii, construction of the Mimulus physical maps, and BAC end-sequencing to aid in the construction of the integrated physical-genetic map.

Funding
This project is supported by NSF-FIBR grant No. 0328636 and NSF-MRI grant No. 0320635.

Links
Mimulus Project Page: http://www.mimulusevolution.org/
CUGI Mimulus guttatus Physical Map
CUGI Mimulus lewisii Physical Map
Filters and clones from three BAC Libraries utilized in the physical maps may be ordered from CUGI's online ordering system.